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About This Reference Document

This guide is a resource for those impacted by endometriosis. It has been created out of an interest in the intersections between patient experiences, research, and provider care. There are glaring gaps in knowledge about endometriosis, from its cause to a cure, due to a lack of research and the complexity of the disease. However, with increased awareness and funding, compelling new research is happening right now. 

 

For patients, this resource includes a symptom guide, facts about the disease, and an overview of current and upcoming research that may support them in their future diagnostic and treatment experiences. 

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For providers, it features highlights from recent studies to stay up to date on developments, with links to the full papers for further consideration. 

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A very exciting part will be when the influx of new research begins to inform clinical practice, and evidence-based treatments will emerge based on the studies tracked here. This resource will exist in that intersection and allow transparency and connection between all those involved in and impacted by endometriosis. 

References 

  1. Szypłowska M, Tarkowski R, Kułak K. The impact of endometriosis on depressive and anxiety symptoms and quality of life: a systematic review. Front Public Health. 2023 Sep 6;11:1230303. doi: 10.3389/fpubh.2023.1230303. PMID: 37744486; PMCID: PMC10512020.

  2. Endometriosis - Symptoms and causes - Mayo Clinic. Mayo Clinic. 2023 Oct 12. https://www.mayoclinic.org/diseases-conditions/endometriosis/symptoms-causes/syc-20354656

  3. Herington JL, Bruner‐Tran KL, Lucas JA, Osteen KG. Immune interactions in endometriosis. Expert Review of Clinical Immunology. 2011;7(5):611–626. https://doi.org/10.1586/eci.11.53. doi:10.1586/eci.11.53

  4. Abramiuk M, Grywalska E, Małkowska P, Sierawska O, Hrynkiewicz R, Niedźwiedzka-Rystwej P. The role of the immune system in the development of endometriosis. Cells. 2022;11(13):2028. https://doi.org/10.3390/cells11132028. doi:10.3390/cells11132028

  5. Bulletti C, Coccia ME, Battistoni S, Borini A. Endometriosis and infertility. J Assist Reprod Genet. 2010 Aug;27(8):441-7. doi: 10.1007/s10815-010-9436-1. Epub 2010 Jun 25. PMID: 20574791; PMCID: PMC2941592.

  6. Nezhat C, Li A, Falik R, Copeland D, Razavi GM, Shakib A, Mihailide C, Bamford H, DiFrancesco L, Tazuke SI, et al. Bowel endometriosis: diagnosis and management. American Journal of Obstetrics and Gynecology. 2018;218(6):549–562. https://doi.org/10.1016/j.ajog.2017.09.023. doi:10.1016/j.ajog.2017.09.023

  7. Coxon L, Wiech K, Vincent K. Is There a Neuropathic-Like Component to Endometriosis-Associated Pain? Results From a Large Cohort Questionnaire Study. Front Pain Res (Lausanne). 2021 Nov 4;2:743812. doi: 10.3389/fpain.2021.743812. PMID: 35295529; PMCID: PMC8915551.

  8. Godin SK, Wagner J, Huang P, Bree D. The role of peripheral nerve signaling in endometriosis. FASEB Bioadv. 2021 Aug 2;3(10):802-813. doi: 10.1096/fba.2021-00063. PMID: 34632315; PMCID: PMC8493968.

  9. Muraoka A, Suzuki M, Hamaguchi T, Watanabe S, Iijima K, Murofushi Y, Shinjo K, Osuka S, Hariyama Y, Ito M, Ohno K, Kiyono T, Kyo S, Iwase A, Kikkawa F, Kajiyama H, Kondo Y. Fusobacterium infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts. Sci Transl Med. 2023 Jun 14;15(700):eadd1531. doi: 10.1126/scitranslmed.add1531. Epub 2023 Jun 14. PMID: 37315109.

  10. Ser HL, Au Yong SJ, Shafiee MN, Mokhtar NM, Ali RAR. Current Updates on the Role of Microbiome in Endometriosis: A Narrative Review. Microorganisms. 2023 Jan 31;11(2):360. doi: 10.3390/microorganisms11020360. PMID: 36838325; PMCID: PMC9962481.

  11. Yang F, Wu Y, Hockey R, Doust J, Mishra GD, Montgomery GW, Mortlock S. Evidence of shared genetic factors in the etiology of gastrointestinal disorders and endometriosis and clinical implications for disease management. Cell Reports Medicine. 2023;4(11):101250. https://doi.org/10.1016/j.xcrm.2023.101250. doi:10.1016/j.xcrm.2023.101250

  12. Fonseca, M.A.S., Haro, M., Wright, K.N. et al. Single-cell transcriptomic analysis of endometriosis. Nat Genet 55, 255–267 (2023). https://doi.org/10.1038/s41588-022-01254-1

  13. Shin S, Chung Y, Moon SW, Choi E-R, Kim M, Chung Y, Lee SH. Single‐cell profiling identifies distinct hormonal, immunologic, and inflammatory signatures of endometriosis‐constituting cells. Journal of Pathology. 2023;261(3):323–334. https://doi.org/10.1002/path.6178. doi:10.1002/path.6178

14. Rahmioglu, N., Mortlock, S., Ghiasi, M. et al. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nat Genet 55, 423–436 (2023). https://doi.org/10.1038/s41588-023-01323-z

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